Recovery of interfering bacteria in the nasopharynx following antimicrobial therapy of acute maxillary sinusitis with telithromycin or amoxicillin-clavulanate.
نویسندگان
چکیده
The effect on the nasopharyngeal flora of 7 days of amoxicillin-clavulanate or 5 days of 800 mg once a day was studied in 50 adults with acute sinusitis. The numbers of potential pathogens and interfering alpha-hemolytic streptococci were equally reduced after both therapies. However, the number of interfering Prevotella spp. declined more significantly after amoxicillin-clavulanate treatment.
منابع مشابه
Effect of telithromycin and azithromycin on nasopharyngeal bacterial flora in patients with acute maxillary sinusitis.
OBJECTIVE To explore the efficacy of the ketolide telithromycin compared with azithromycin in eradicating S pneumoniae from the nasopharynx of adults with acute maxillary sinusitis. The growing resistance of Streptococcus pneumoniae to penicillin and macrolides brought about the development of a new class of antibiotics-the ketolides-that are effective against resistant pneumococci. SETTING O...
متن کاملReport from the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy.
The ketolide telithromycin (Ketek, Sanofi Aventis) has been found to be more effective than the macrolide azithromycin (Zithromax, Pfizer) in eradicating Streptococcus pneumoniae from the nasopharynges of patients with acute maxillary sinusitis. Furthermore, the emergence of antimicrobial resistance following therapy occurs only with azithromycin. The growing resistance of S. pneumoniae to peni...
متن کاملA combination of amoxicillin and clavulanate every 12 hours vs every 8 hours for treatment of acute bacterial maxillary sinusitis.
OBJECTIVE To compare the safety and efficacy of a combination of amoxicillin and clavulanate potassium given orally every 12 hours (amoxicillin, 875 mg; clavulanate, 125 mg) with that given every 8 hours (amoxicillin, 500 mg; clavulanate, 125 mg) for the treatment of patients with acute bacterial maxillary sinusitis. DESIGN Multicenter double-blind randomized double-dummy controlled trial. ...
متن کاملBacterial interference in the nasopharynx following antimicrobial therapy of acute otitis media.
The effect on the nasopharyngeal bacterial flora of therapy for 10 days with co-amoxiclav or cefprozil was studied in 50 children with acute otitis media. Before therapy, potential pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis) were isolated in 14 (56%) of those treated with co-amoxiclav and 15 (60%) of those treated with cefprozil. Following therapy, the...
متن کاملMicrobiology of acute complicated bacterial sinusitis at the University of the Witwatersrand.
DESIGN A retrospective chart review study at two referral hospitals identified 226 consecutive surgical patients with acute complicated sinusitis. SUBJECTS One hundred and fifty-nine male and 67 female patients, with a mean age of 16.5 (standard deviation 0.7) years, underwent external fronto-ethmoidectomy with maxillary sinus washout and 13 had a concurrent craniotomy. RESULTS A total of 2...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 11 شماره
صفحات -
تاریخ انتشار 2005